重度抑郁症患者血清CXCL1、CCL11 水平与生活事件 和自杀意念的关系研究.

Objective:To explore the relationship between serum C-X-C motif chemokine ligand 1 (CXCL1) and C-C motif chemokine 11 (CCL11) levels and life events and suicidal ideation in patients with major depressive disorder (MDD). Methods:The 100 patients with MDD who were admitted to our hospital from January 2020 to June 2021 were selected as the case group, and 100 volunteers who underwent physical examination in our hospital in the same period were selected as the control group. The serum CXCL1 and CCL11 levels and the life event scale (LES) evaluation results were compared between the two groups of subjects. Pearson method was used to analyze the correlation between LES evaluation results and CXCL1 and CCL11 levels. 100 patients with MDD were divided into suicide ideation group (n=45) and non-suicide ideation group (n=55) according to whether they had suicide ideation. The related influencing factors of suicide ideation in patients with MDD were analyzed by univariate and multivariate Logistic regression. Results: The serum CXCL1, CCL11 levels, negative event stimulation amount and life event stress total score in case group were higher than those in control group (P<0.05), while positive event stimulation amount was lower than that in control group (P<0.05). The serum CXCL1 and CCL11 levels were positively correlated with the negative event stimulation amount(P<0.05). The results of this study showed that the incidence of suicidal ideation in patients with MDD was 45.00% during the investigation period. There were statistically significant differences in gender, family history of suicide attempt, combined with anxiety symptoms, psychoticism, neuroticism, introversion-extroversion, cover-up, CXCL1, CCL11, negative event stimulation amount and life event stress total score between the suicidal ideation group and the non-suicidal ideation group (P<0.05). Multivariate Logistic regression analysis showed that gender, psychoticism, neuroticism, serum CXCL1 and CCL11 levels and negative event stimulation amount were the influencing factors for the occurrence of suicidal ideation in patients with MDD. Conclusion: The serum CXCL1 and CCL11 levels in patients with MDD are increased. There is a certain correlation between the serum CXCL1 and CCL11 levels and negative event stimulation amount. The patients with MDD have a high probability of suicidal ideation, and the serum CXCL1 and CCL11 levels and negative event stimulation amount are the influencing factors of suicidal ideation. In clinical work, we should actively take countermeasures against the relevant influencing factors. [ABSTRACT FROM AUTHOR]