Photoprotective effect of 18β-glycyrrhetinic acid derivatives against ultra violet (UV)-B-Induced skin aging.

[Display omitted] • Thirty-two benzylidene derivatives of Glycyrrhetinic acid were synthesized as photoprotective agents against UV-B -induced skin photoageing. • In vitro biological evaluation on Human Dermal Fibroblast (HDF) cell lines. • Compounds A01, A05, A15, A22, A23, A25, A26, A28, A29, A32, A33, and A34 significantly enhanced cell viability of HDFs. • Compound A33 at 10 μM and 25 μM showed a significant photo-protective effect against UV-B (10 mJ/cm2) –induced damage in HDFs. • A33 at 25 μ M significantly restored the UV-B -induced damage via its potent anti-oxidant, anti-apoptotic effects and ability to prevent collagen degradation. These findings pave the way for further development of A33 as a photo-protective skin agent. • Molecular Modelling against MMP1 protein. Excessive exposure to sun can harm the skin, causing sunburn, photo-aging, and even skin cancer. Different benzylidene derivatives (A02-A18 and A19-A34) of 18β-Glycyrrhetinic acid (A01) were designed and synthesized in an effort to discover photo-protective compounds against UV-B -induced skin aging. The synthesized derivatives were subjected to cellular viability test using MTT assay in primary Human Dermal Fibroblasts (HDFs). The results indicate A01, A05, A15, A22, A23, A25, A26, A28, A29, A32, A33, and A34 significantly enhanced cell viability of HDFs. Compound A33 at 10 and 25 μM showed a significant photo-protective effect against UV-B (10 mJ/cm2) –induced damage in HDFs. A33 at 25 μ M significantly restored the UV-B -induced damage via its potent anti-oxidant, anti-apoptotic effects and ability to prevent collagen degradation. These findings pave the way for further development of A33 as a photo-protective skin agent. [ABSTRACT FROM AUTHOR]