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Palladium‐catalyzed Atroposelective Interannular C−H Arylation of Biaryl Aldehydes with Aryl Iodides Enabled by a Transient Directing Group Strategy.
- Source :
-
Advanced Synthesis & Catalysis . 10/18/2022, Vol. 364 Issue 20, p3589-3599. 11p. - Publication Year :
- 2022
-
Abstract
- A concise synthesis of axially chiral biaryl aldehydes through Pd/amino acid‐catalyzed atroposelective interannular C−H arylation of biaryl aldehydes with aryl iodides is developed. This reaction proceeds smoothly involving excellent enantiocontrol and accomplishes with good tolerance of functional groups. Moreover, the readily accessible scale‐up synthesis and further transformation of products has highlighted the potential utility of this asymmetric catalytic protocol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARYL iodides
*ARYLATION
*ALDEHYDES
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 364
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 159764676
- Full Text :
- https://doi.org/10.1002/adsc.202200659