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Anti-obesity, anti-hyperglycaemic, anti-antipyretic and analgesic activities of Globularia alypum extracts.
- Source :
-
Archives of Physiology & Biochemistry . Dec2022, Vol. 128 Issue 6, p1453-1460. 8p. - Publication Year :
- 2022
-
Abstract
- The aim of this study is to evaluate the anti-obesity, anti-hyperglycaemic, analgesic and antipyretic activities of Globularia alypum (GA). GA methanol and water extracts (GAME, GAWE) were administered to high-fat-high-glucose diet (HFFD) rats. This study showed that GAME exhibited the highest antioxidant, anti-α-amylase and anti-lipase activities, with half inhibitory concentration (IC50) values 0.067, 1.05 and 2.97 mg/ml respectively. In HFFD rats, the administration of GAME inhibited lipase activity by 36, 37 and 30% in the intestine, pancreas and serum, respectively, reduced body weight by 17.7% and modulated lipid profile. In addition, administration of GAME to HFFD-rats decreased α-amylase activity, improved glucose level and protected liver function. Furthermore, the administration of GA extracts to rats revealed antipyretic (reduction in writhing by 64%) and analgesic (decrease of temperature by 1.11 °C) activities. This study showed that GA extracts exhibited an anti-obesity, anti-hyperglycaemia, anti-pyretic and analgesic activities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BODY weight
*AMYLASES
*EXTRACTS
*WEIGHT loss
*LIPASES
*DIGESTIVE enzymes
Subjects
Details
- Language :
- English
- ISSN :
- 13813455
- Volume :
- 128
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Archives of Physiology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 159811897
- Full Text :
- https://doi.org/10.1080/13813455.2020.1773865