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The combination of in situ photodynamic promotion and ion-interference to improve the efficacy of cancer therapy.
- Source :
-
Journal of Colloid & Interface Science . Jan2023:Part A, Vol. 629, p522-533. 12p. - Publication Year :
- 2023
-
Abstract
- [Display omitted] Photodynamic therapy (PDT) is proved to be a promising modality for clinical cancer treatment. However, it also suffers from a key obstacle in association with its oxygen-dependent nature which greatly limits its effective application against hypoxic tumors. Herein, on the basis of the unique property of calcium peroxide (CaO 2), we propose an O 2 -self-supply strategy for the promotion of PDT by combining the in situ O 2 -generation characteristic of calcium peroxide with the photosensitive nature of porphyrin. A shell of ZIF-8 was synthesized surround the CaO 2 core to prevent the CaO 2 from premature decomposition and increased the loading of THPP efficiently. Depending on the in situ self-supply of O 2 , the photosensitizer was able to exhibit an enhanced PDT effect that significantly inhibit the growth of tumor. Moreover, the enrichment of free calcium ions derived from the decomposition of CaO 2 under acidic tumor microenvironment also shows the unique ion-interference effect and contributes to the obvious inhibition against tumor growth. This work presents a synergistic strategy for the construction of a photodynamic promotion/ion-interference combined nano-platform which can also serve as an inspiration for the future design of effective nanocomposites in tumor treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER treatment
*CALCIUM ions
*PHOTODYNAMIC therapy
*TUMOR growth
*TUMOR treatment
Subjects
Details
- Language :
- English
- ISSN :
- 00219797
- Volume :
- 629
- Database :
- Academic Search Index
- Journal :
- Journal of Colloid & Interface Science
- Publication Type :
- Academic Journal
- Accession number :
- 159820586
- Full Text :
- https://doi.org/10.1016/j.jcis.2022.08.125