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Germanene-modified chitosan hydrogel for treating bacterial wound infection: An ingenious hydrogel-assisted photothermal therapy strategy.
- Source :
-
International Journal of Biological Macromolecules . Nov2022, Vol. 221, p1558-1571. 14p. - Publication Year :
- 2022
-
Abstract
- The elaborate design of an ingenious hydrogel-assisted photothermal therapy (PTT) platform is a promising strategy for treating bacterial wound infections. Herein, a new generation of germanene nanocrystals (Ge NCs) with excellent photothermal performance are prepared via an ice-bath sonication liquid-phase exfoliation technique. Whereafter, by crosslinking interaction between chitosan and zinc acetate, as well as self-assembly property between Ge NCs and chitosan, we successfully construct an innovative germanene-modified chitosan antimicrobial hydrogel (CS/Ge NCs0.8) integrating capture and killing bacteria performances. When co-cultured with bacteria, CS/Ge NCs0.8 hydrogel with the positive charge can adsorb and restrict bacteria in the range of PTT destruction. Once the near-infrared laser is introduced, CS/Ge NCs0.8 hydrogel will effectively convert light energy into localized heat, further inducing bacterial death. By this entirely novel modality, CS/Ge NCs0.8 hydrogel exhibits marvelous antibacterial property against E. coli and S. aureus in vitro. Furthermore, in vivo studies demonstrate that CS/Ge NCs0.8 hydrogel possesses the ability to significantly rescue S. aureus -induced skin wound infections, suggesting CS/Ge NCs0.8 hydrogel can be served as an antibacterial dressing. Strikingly, this is the first-ever report of CS/Ge NCs0.8 hydrogel in the antibacterial field, which may spur a wave of developing Ge-based biomaterials to benefit biomedical applications. [Display omitted] • Hydrogel was prepared by virtue of multiple crosslinking interaction. • Hydrogel possessed excellent photothermal conversion performance. • Hydrogel featured antibacteria and adsorption capacities to bacteria. • The antibacterial platform could kill 98.76 % E. coli and 99.81 % S. aureus. • Wound infection model experiments confirmed the antibacterial activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 221
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 159857625
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2022.09.128