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Neutrophil Count as Atrioventricular Block (AVB) Predictor following Pediatric Heart Surgery.

Authors :
Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Gładki, Marcin
Michalak, Michał
Sochacki, Mateusz
Weclewska, Anita
Zalas, Dominika
Bobkowski, Waldemar
Jemielity, Marek
Source :
International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 20, p12409-N.PAG. 12p.
Publication Year :
2022

Abstract

Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications' risk in pediatric cardiac congenital surgery. The retrospective single center analysis included 93 pediatric patients (48 (65%) males and 45 (35%) females), mean age of 7 (3–30) months referred for cardiac surgery in cardiopulmonary bypass due to functional single ventricle disease (26 procedures), shunts lesions (40 procedures) and cyanotic disease (27 procedures). Among simple hematological indices, the receiver-operating-characteristic curve showed that a neutrophil count below 2.59 K/uL was found as an optimal cut-off point for predicting postoperative atrioventricular block following pediatric cardiac surgery (AUC = 0.845, p < 0.0001) yielding a sensitivity of 100% and a specificity of 65.62%. Preoperative values of neutrophil count below 2.59 K/uL in whole blood analysis can be regarded as a predictive factor (AUC = 0.845, p < 0.0001) for postoperative atrioventricular block in pediatric cardiac surgery. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
23
Issue :
20
Database :
Academic Search Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
159905090
Full Text :
https://doi.org/10.3390/ijms232012409