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Development of Green Differential Pulse Voltammetric Strategy for the Determination of Alfuzosin Hydrochloride at Pencil Graphite and Modified Carbon Paste Electrodes.
- Source :
-
Acta Chimica Slovenica . 2022, Vol. 69 Issue 3, p507-518. 12p. - Publication Year :
- 2022
-
Abstract
- A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimized using cyclic voltammetry, showing an irreversible anodic peak in Britton-Robinson buffered medium (pH 6) at 0.86-0.90 V. The electrochemical responses were linearly correlated with alfuzosin concentrations (R2 > 0.999) in the ranges of 0.6-20 and 0.3-20 µM, exhibiting higher electrocatalytic activity at PGE with a low detection limit/detectability of 0.099 µM. In addition, this study was a successful attempt for the drug determination in tablets and spiked urine samples with green profile evaluation, employing the National Environmental Methods Index, analytical Eco-Scale score, and Green Analytical Procedure Index. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13180207
- Volume :
- 69
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Acta Chimica Slovenica
- Publication Type :
- Academic Journal
- Accession number :
- 159945279
- Full Text :
- https://doi.org/10.17344/acsi.2022.7348