Csp3–H Bond Functionalization of α-Bromo Ketones for the Synthesis of α-Keto Thioamides Using Elemental Sulfur.

An efficient metal- and additive-free synthesis of α-keto thioamides has been developed via sulfur oxidation of the Csp3–H bond of α-bromo ketones with amines. This environmentally friendly strategy made it possible to synthesize a wide series of α-keto thioamides with broad functional group tolerance. [ABSTRACT FROM AUTHOR]