The effect of the interaction between the EXT2 gene, the KCNJ11 gene single nucleotide polymorphisms and blood glucose on the susceptibility to metabolic syndrome with Yin deficiency syndrome.

Objective To investigate the effect of the interaction between single nucleotide polymorphisms of the EXT2 gene and the KCNJ11 gene and blood glucose on the susceptibility to metabolic syndrome with Yin deficiency syndrome. Methods Multiple single nucleotide polymorphism (SNP) typing techniques were used to detect SNPs in metabolic syndrome patients with Yin deficiency or non-yin deficiency syndrome and healthy people. The SHEsis software was used to analyze the genes of three groups of participants. A generalized multifactor dimensionality reduction combined with a logistic regression model was used to detect the effect of the interaction between the SNPs and blood glucose on the metabolic syndrome with Yin deficiency syndrome. Results Individuals with the KCNJ11 gene rs5215-C allelic polymorphism (CT + CC) had a risk of metabolic syndrome with Yin deficiency syndrome being 0.947 times higher than those with TT (P > 0.05). Individuals with the EXT2 gene rsll037909-C allelic polymorphism (CT + CC) had a risk of metabolic syndrome being 1.839 times higher than those with TT (P < 0.05). The model composed of the rs11037909 locus of the EXT2 gene and blood glucose was the best model related to the risk of metabolic syndrome with Yin deficiency syndrome (P = 0.001). Individuals with the CT/CC genotype but without hyperglycemia had a 4. 216 times higher risk of metabolic syndrome with Yin deficiency syndrome compared with those with the TT genotype but without hyperglycemia (P < 0.05). Individuals with hyperglycemia and the TT genotype had a 3. 737 times higher risk of metabolic syndrome with Yin deficiency syndrome compared with those with the same genotype but without hyperglycemia. (P <0.05). Conclusion Carrying the rs5215-C allele of the KCNJ11 gene did not increase the susceptibility to metabolic syndrome Yin deficiency syndrome. The rs11037909-C allele of the EXT2 gene was a risk factor for metabolic syndrome. The interaction between rs11037909 of the EXT2 gene and blood glucose will increase the susceptibility to metabolic syndrome with Yin deficiency syndrome. Both the rs11037909-C allele and hyperglycemia were risk factors for metabolic syndrome with Yin deficiency syndrome. After two risk factors interacted, the risk of developing metabolic syndrome with Yin deficiency syndrome was higher than those without risk factors. [ABSTRACT FROM AUTHOR]