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Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis.
- Source :
-
Cardiovascular Diabetology . 11/2/2022, Vol. 21 Issue 1, p1-16. 16p. - Publication Year :
- 2022
-
Abstract
- Background: The triglyceride glucose (TyG) index, which is a new surrogate indicator of insulin resistance (IR), is thought to be associated with many diseases, such as cardiovascular disease, but its relationship with cerebrovascular disease is still controversial. Methods: The PubMed, EMBASE, Cochrane Library, Web of Science and Medline databases were searched until March 2022 to evaluate the association between the TyG index and cerebrovascular disease risk. A random‒effects model was used to calculate the effect estimates and 95% confidence intervals (CIs). Results: A total of 19 cohort studies and 10 case‒control/cross‒sectional studies were included in our study, which included 11,944,688 participants. Compared with a low TyG index, a higher TyG index increased the risk of cerebrovascular disease (RR/HR = 1.22, 95% CI [1.14, 1.30], P< 0.001; OR = 1.15, 95% CI [1.07, 1.23], P< 0.001). Furthermore, the results of the dose-response analysis of the cohort study demonstrated that the risk of cerebrovascular disease increased by 1.19 times per 1 mg/dl increment of the TyG index (relative risk = 1.19, 95% CI [1.13,1.25], P< 0.001). Conclusion: TyG index is related to cerebrovascular disease. More data and basic research are needed to confirm the association. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cardiovascular Diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 160027637
- Full Text :
- https://doi.org/10.1186/s12933-022-01664-9