Factors associated with bone erosion in patients with gout: A dual-energy gemstone spectral imaging computed tomography study.

Objectives: This study aimed to assess the factors influencing bone erosion (BE) in patients with gout using dual-energy gemstone spectral imaging computer tomography. Methods: We compared the clinical data, laboratory indices, and tissue urate levels at the monosodium urate (MSU) bone interface measured by dual-energy gemstone spectral imaging computed tomography of 87 gout patients with (n=41) and without (n=46) BE. Logistic regression analysis was used to investigate the risk factors associated with BE. Results: In total, 47.1% of patients with gout had BE. The disease duration, serum uric acid, tissue urate levels, and the presence of tophi were significantly higher (p< .05) in gout patients with BE than in those without BE. Longer disease duration (odds ratio=1.11, 95% confidence interval: 1.00-1.24, p< .05) and increased tissue urate levels (odds ratio=1.01, 95% confidence interval: 1.00-1.02, p< .05) were independently associated with BE. Tissue urate levels at the MSU-bone interface were correlated with the presence of tophi (r=0.62, p< .001), BE (r =0.51, p< .001), renal calculus (r =0.24, p=.03), and serum uric acid levels (r =0.23, p=.03). Conclusions: This study found that longer disease duration and elevated tissue urate concentrations at the MSU-bone interface were associated with BE in patients with gout. [ABSTRACT FROM AUTHOR]