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Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells.
- Source :
-
Journal of Oncology . 11/10/2022, p1-14. 14p. - Publication Year :
- 2022
-
Abstract
- Increasing evidence shows that alterations in microRNA (miRNA) expression are involved in the occurrence and development of various malignant tumors, including colon cancer. MiRNA-524-5p has been reported to have anticancer activity in colon cancer. This study explored the influence of the miRNA-524-5p/CXCR7 axis on angiogenesis using colon cancer cells and further studied the mechanisms involved. We found that changing the expression of miRNA-524-5p can affect colonic proliferation, migration, and angiogenesis. Furthermore, angiogenesis induced by miRNA-524-5p overexpression was reversed by overexpression of CXCR7 in HT-29 cells, while the opposite was observed in Caco-2 cells. Furthermore, miRNA-524-5p inhibited the activation of AKT and ERK signaling by targeting CXCR7. Overall, our results indicated that the miRNA-524-5p/CXCR7 axis regulated angiogenesis in colon cancer cells through the AKT and ERK pathways. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16878450
- Database :
- Academic Search Index
- Journal :
- Journal of Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 160142050
- Full Text :
- https://doi.org/10.1155/2022/7224840