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Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment.
- Source :
-
International Journal of Molecular Sciences . Nov2022, Vol. 23 Issue 21, p13655. 15p. - Publication Year :
- 2022
-
Abstract
- There has been little understanding of acidification functionality in wound healing, highlighting the need to study the efficacy of wound acidification on wound closure and cellular activity in non-infected wounds. This study is focused on establishing the healing potential of wound acidification in non-infected wounds. Acidic buffers, constituting either phosphoric or citric acid, were employed to modify the physiological pH of non-infected full-thickness excisional murine wounds. Acidification of the wound by acidic buffers was found to be an effective strategy to improve wound healing. A significant improvement in wound healing parameters was observed as early as 2 days post-treatment with acidic buffers compared to controls, with faster rate of epithelialization, wound closure and higher levels of collagen at day 7. pH is shown to play a role in mediating the rate of wound healing, with acidic buffers formulated at pH 4 observed to stimulate faster recovery of wounded tissues than pH 6 buffers. Our study shows the importance of maintaining an acidic wound microenvironment at pH 4, which could be a potential therapeutic strategy for wound management. [ABSTRACT FROM AUTHOR]
- Subjects :
- *WOUND healing
*CITRIC acid
*WOUNDS & injuries
*PHOSPHORIC acid
*ACIDIFICATION
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 23
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 160146384
- Full Text :
- https://doi.org/10.3390/ijms232113655