Connexin43 in Post-Surgical Peritoneal Adhesion Formation.

Studying the Role of Cx43 during Peritoneal Adhesion Formation Mouse Cx43 antisense oligodeoxynucleotide, Cx43asODN (5'-GTAATTGCGGCAGGAGGAATTGTTTCTGTC-3') was administered to the IB peritoneal adhesion to investigate the role of Cx43 in adhesion formation [[12]]. Effect of Cx43asODN Treatment on Inflammation during Early Adhesion Formation At both 6 and 24 h post-surgery, Cx43asODN treatment showed a mild reduction in inflammation OIB ( I p i = 0.528, I p i = 0.222, respectively) and a more significant reduction WIB when compared to control ( I p i <= 0.01) (Figure 5). Inhibition of Cx43 expression in Cx43 SP +/- sp transgenic mice or through Cx43asODN treatment in CKD models significantly reduced cell adhesion markers, monocyte infiltration and interstitial renal fibrosis [[26]]. Graph: Figure 2 Cx43asODN significantly reduced Cx43 protein levels in the regions within the IB at 24 h post-surgery. Significant Upregulation of Cx43 in IB during Early Adhesion Formation Cx43 protein levels were investigated at 0, 6, and 24 h post-surgery (Figure 1A and Figure S3. [Extracted from the article]