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pKa and Partition coefficient Determination of Montelukast sodium by Spectrophotometric and HPLC Technique.
- Source :
-
Journal of Pharmaceutical Negative Results . 2022 Special Issue, Vol. 13, p2130-2140. 11p. - Publication Year :
- 2022
-
Abstract
- The acid dissociation constant (pKa) of a pharmaceutical drug is a significant physicochemical parameter that impacts biopharmaceutical properties of drugs and other chemical characteristics. Determination of pKa and Partition coefficient of Montelukast Sodium by spectrophotometric technique and HPLC technique individually. From the measurement structure plan of dosage form and pharmaceutical examination point of view, the pKa and Partition coefficient are the most significant physicochemical properties of pharmaceutical drug which should be assessed. The pKa estimation of Montelukast Sodium was done by utilizing UV-Visible spectrophotometric strategy and Partition coefficient was evaluated utilizing HPLC technique. Experimental estimation value of pKa1 of Montelukast Sodium was found to be 3.3 and pKa2 of Montelukast Sodium was found to be 4.4. Two graphical techniques were utilized to estimate the acid dissociation constant (pKa) for Montelukast Sodium and the Partition coefficient of Montelukast Sodium by HPLC method was experimentally estimated to be 2.42. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MONTELUKAST
*HIGH performance liquid chromatography
*SODIUM
*DOSAGE forms of drugs
Subjects
Details
- Language :
- English
- ISSN :
- 09769234
- Volume :
- 13
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmaceutical Negative Results
- Publication Type :
- Academic Journal
- Accession number :
- 160278815
- Full Text :
- https://doi.org/10.47750/pnr.2022.13.S01.249