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Fentanyl enhances HIV infection in vitro.
- Source :
-
Virology . Dec2022, Vol. 577, p43-50. 8p. - Publication Year :
- 2022
-
Abstract
- Acquired immunodeficiency syndrome (AIDS) caused by Human immunodeficiency virus type 1 (HIV-1) has a high tendency among illicit drug abusers. Recently, it is reported that abuse of fentanyl, a potent synthetic μ receptor–stimulating opioid, is an independent risk factor for HIV-1 infection. However, the mechanism of action in augmenting HIV-1 infection still remains elusive. In this study, we found that fentanyl enhanced infection of HIV-1 in MT2 cells, primary macrophages and Jurkat C11 cells. Fentanyl up-regulated CXCR4 and CCR5 receptor expression, which facilitated the entry of virion into host cells. In addition, it down-regulated interferon-β (IFN-β) and interferon-stimulated genes (APOBEC3F, APOBEC3G and MxB) expression in MT2 cells. Our findings identify an essential role of fentanyl in the positive regulation of HIV-1 infection via the upregulation of co-receptors (CXCR4/CCR5) and downregulation of IFN-β and ISGs, and it may have an important role in HIV-1 immunopathogenesis. • Fentanyl enhances infection of HIV-1 in MT2, primary macrophages, Jurkat C11 cells. • Fentanyl promotes the expression of CXCR4 and CCR5 receptors. • Fentanyl inhibits interferon-β and interferon-stimulated genes expression. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infections
*AIDS
*FENTANYL
*OPIOID receptors
*HIV
*CXCR4 receptors
Subjects
Details
- Language :
- English
- ISSN :
- 00426822
- Volume :
- 577
- Database :
- Academic Search Index
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 160291658
- Full Text :
- https://doi.org/10.1016/j.virol.2022.10.004