An update on the role of tumor necrosis factor alpha stimulating gene-6 in inflammatory diseases.

At present, the occurrence and development of inflammatory diseases are closely related to the abnormal changes of the content and function of many cytokines. At the same time, targeting related cytokines to prevent and treat diseases has also achieved good results. Therefore, it is very important to explore the role of various cytokines in inflammatory diseases. As an inflammation related protein, Tumor necrosis factor alpha stimulating gene-6 (TSG-6) has attracted more and more attention. In the process of disease, it's like a double-edged sword, showing different responses. It is constitutively expressed in some tissues with high metabolic activity and barrier protection. The diversity of its functions depends on the binding of TSG-6 with a variety of ligands, including matrix molecules, autoimmune regulatory factors and growth factors, participating in extracellular matrix remodeling and regulating protease network. This paper reviews the structure, biological function and research progress of TSG-6 in inflammatory diseases, in order to provide reference for drug development in the future. • We describe TSG-6 and its ligands, which play important roles on extracellular matrix remodeling and anti-inflammatory. • We discuss the mechanisms that TSG-6 binding to its ligands, regulating tissue repair, cell function and immune response. • We discuss the role of TSG-6 in inflammatory diseases and its feasibility as a therapeutic target. [ABSTRACT FROM AUTHOR]