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A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing.
- Source :
-
Chemical Communications . 12/7/2022, Vol. 58 Issue 94, p13107-13110. 4p. - Publication Year :
- 2022
-
Abstract
- A programmed DNA–Au nanomachine has been constructed to achieve in situ imaging of transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger gene silencing therapy. The results of MCF-7 cell-specific imaging and apoptosis experiments demonstrate that the nanomachine provides a valuable nanotheranostic platform for accurate multi-site imaging and intracellular gene silencing. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENE silencing
*GENE therapy
*DNA adducts
*GOLD clusters
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 94
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 160404253
- Full Text :
- https://doi.org/10.1039/d2cc05017j