Effect of Obesity among Hospitalized Cancer Patients with or without COVID-19 on a National Level.

Simple Summary: Few papers have looked for an association between obesity and mortality risk in cancer patients with COVID-19 but, to our knowledge, none have studied this association in relation to the severity of obesity. We performed a study using data from the French national hospital database to study the effect of obesity (and its severity) on the risk of intensive care unit (ICU) admission, severe complications, and in-hospital mortality in cancer patients hospitalized for COVID-19 or not. The risk of ICU admission or severe complications was higher in cancer patients with obesity compared to cancer patients without obesity, regardless of cancer type and obesity severity. We did not find an excess obesity-related risk for in-hospital mortality, except for massive obesity in COVID-19 patients with hematological cancer and in non-COVID-19 patients with solid cancer. Further studies are warranted to better understand the relationship between obesity, and especially massive obesity, the prognosis of SARS-CoV-2 infection in cancer patients. Cancer and obesity are well-known prognostic factors in COVID-19. Our objective was to study the effect of obesity (and its severity) on the risk of intensive care unit (ICU) admission, severe complications, and in-hospital mortality, in a population of cancer patients hospitalized with or without COVID-19. All patients hospitalized in France for cancer from 1 March 2020 to 28 February 2022 were included from the French national administrative database. The effect of obesity was estimated in COVID-19 and in non-COVID-19 cancer patients using logistic and survival regressions, taking into account age, sex, comorbidities, and different types of cancer. Among the 992,899 cancer patients, we identified 53,090 patients with COVID-19 (5.35%), of which 3260 were obese (6.1%). After adjustment, for patients with or without COVID-19, there is an increased risk of ICU admission or severe complications in obese patients, regardless of the type of obesity. Regarding in-hospital mortality, there is no excess risk associated with overall obesity. However, massive obesity appears to be associated with an increased risk of in-hospital mortality, with a significantly stronger effect in solid cancer patients without COVID-19 and a significantly stronger effect in hematological cancer patients with COVID-19. This study showed that in France, among hospitalized patients with cancer and with or without COVID-19, increased vigilance is needed for obese patients, both in epidemic and non-epidemic periods. This vigilance should be further strengthened in patients with massive obesity for whom the risk of in-hospital mortality is higher, particularly in epidemic periods for patients with hematological cancers. [ABSTRACT FROM AUTHOR]