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Analysis of the relationship between the expression of EBV-related antibodies and ET-1 axis in gastric cancer.
- Source :
-
Cancer Biomarkers . 2022, Vol. 35 Issue 3, p321-329. 9p. - Publication Year :
- 2022
-
Abstract
- BACKGROUND AND OBJECTIVE: EBV-associated gastric cancer (EBVaGC) is a distinct subtype of GC, and EBV plays an important role in tumor progress. The standard method to identify EBV-positive tumor is determined by in situ hybridization for EBV-encoded EBERs in tumor tissues. The present study aims to detect the serological expression of EBV-related antibodies and ET-1 axis to provide a noninvasive method for diagnosis of EBVaGC. METHODS: The content of EBV-related antibodies and ET-1 axis in preoperative peripheral blood of GC was performed by Chemiluminescence and ELISA assay. The EBV DNA copy number was measured by qRT-PCR. RESULTS: The results showed that the levels of anti-EBV early antigen (EA) IgG, viral capsid antigen (VCA) IgA, nuclear antigen (NA) IgG, and EBV DNA copy number were significantly higher in EBVaGC. The ET-1 axis level was much lower in EBVaGC than EBVnGC. CONCLUSIONS: The combined detection of specific anti-EBV antibodies and ET-1 axis might provide new molecular markers for the identification of EBVaGC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15740153
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cancer Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 160460864
- Full Text :
- https://doi.org/10.3233/CBM-220001