冠心病患者血清成纤维细胞生长因子 23、碱性磷酸酶及胎球蛋白 A 水平 与冠状动脉钙化的关系及其预测价值分析.

Objective: To analyze the relationship between serum fibroblast growth factor 23（FGF23）, alkaline phosphatase（ALP）and fetuin-A（FA） levels and coronary artery calcification（CAC） in patients with coronary heart disease（CHD） and to explore their predictive value for CAC. Methods: 165 patients with CHD who were admitted to our hospital from February 2021 to February 2022 were selected, and they were divided into CAC group（n=73） and no-CAC group（n=92） according to whether they were accompanied by CAC or not. Clinical data of the patients were collected, and serum FGF23, ALP and FA levels were measured by enzyme-linked immunosorbent assay（ELISA）. The influencing factors of CAC in patients with CHD were analyzed by multivariate Logistic regression, and the predictive value of serum FGF23, ALP and FA levels on CAC in patients with CHD was drawed by receiver operating characteristic（ROC）curves. Results: Serum FGF23 and ALP levels in the CAC group were higher than in the no-CAC group, and FA level was lower than thae in the no-CAC group（all P<0.01）. Multivariate Logistic regression analysis showed that that age（older）（OR=1.220, 95% CI:1.087～1.369）, hypertension（OR=1.461, 95%CI:1.062～2.010）, blood calcium（higher）（OR=1.532, 95%CI:1.042～2.251）, blood phosphorus（higher）（OR=1.209, 95%CI:1.097～1.333）, FGF23（higher）（OR=1.012, 95%CI: 1.007～1.018）, ALP（higher）（OR=1.046,95%CI:1.023～1.070） were independent risk factors for CAC in patients with CHD, FA（higher）（OR=0.827, 95%CI:0.750～0.912） was independent protective factor（all P<0.05）. ROC curve analysis showed that the area under the curve（AUC） of serum FGF23, ALP and FA were 0.790, 0.773, 0.786 and 0.915, respectively, and the AUC of serum FGF23, ALP and FA in combination with CHD was greater than that of each indicator alone. Conclusion: The serum FGF23 and ALP levels increased and serum FA level decreased are closely related to the occurrence of CAC in patients with CHD, which can be used as auxiliary predictors of THE occurrence of CAC in patients with CHD, and the combined prediction value of the three indicators is high in the risk of CAC in patients with CHD. [ABSTRACT FROM AUTHOR]