利妥昔单抗治疗肾病综合征患者效果观察及对视黄醇结合蛋白、 微循环状态的影响分析.

Objective: To explore and analysis the effects of Rituximab（RTX） in the treatment of patients with nephrotic syndrome and its effect on retinolbinding protein（RBP） and microcirculation state. Methods: From September 2018 to November 2021, 66 cases of patients with nephrotic syndrome who were diagnosed and treated in our hospital were selected as the research subjects. All patients were numbered according to the order of admission, and divided into rituximab group and matched group according to treatment methods, 33 patients in each group. The matched group were given glucocorticoid treatment, and the rituximab group were given rituximab treatment on the basis of the treatment of the matched group. The treatment were observed for 3 months, and the changes of serum RBP and microcirculation status were observed and detected. Results: After treatment, the total effective rates of the rituximab group were 97.0 %, which were higher than that of the matched group 81.8 %（P<0.05）. The quantitative and qualitative levels of urinary protein in the two groups after treatment were lower than before, and the plasma albumin in the rituximab group was lower than that in the control group, while the plasma albumin in the rituximab group was higher than that in the matched group（P<0.05）. After treatment, the nailfold microcirculation tube and flow state scores in the two groups were lower than those before treatment, and the rituximab group were lower than that in the matched group（P<0.05）. The serum RBP levels in the two groups after treatment were lower than those before treatment, and the rituximab group were lower than that in the matched group（P<0.05）. The adverse reactions during the two groups were no difference compared between the two groups（P>0.05）. Conclusion: Rituximab in the treatment of patients with nephrotic syndrome can effectively improve the microcirculation state, inhibit the expression of serum RBP, improve the therapeutic effect, and improve the renal function of patients, and has good safety. [ABSTRACT FROM AUTHOR]