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Activatable Multimodal Probes for In Vivo Imaging and Theranostics.
- Source :
-
Angewandte Chemie International Edition . 12/12/2022, Vol. 61 Issue 50, p1-19. 19p. - Publication Year :
- 2022
-
Abstract
- Multimodal imaging, which harnesses two or more imaging modalities to produce complementary anatomical and molecular information of a living subject, has become as a powerful tool in both basic biomedical research and clinical diagnosis. The progresses in multimodal imaging are paralleled by the advances in multimodal probes, particularly activatable multimodal imaging probes that can generate concurrent switches in different imaging modality signals upon interaction with a molecular target. These probes are extremely promising for in vivo imaging. In this Minireview, we summarize the recent progress in activatable multimodal probes for in vivo imaging and cancer theranostics, focusing on their design principle, signal activation mechanism and biomedical applications. The current challenges and perspectives for future developments of activatable multimodal probes are also briefly discussed. We hope that this Minireview will provide inspiration for the design of other activatable multimodal probes for improving in vivo imaging and theranostics. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COMPANION diagnostics
*DRUG target
*MEDICAL research
*MOLECULAR interactions
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 61
- Issue :
- 50
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 160589411
- Full Text :
- https://doi.org/10.1002/anie.202209512