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Synthesis of licarin A from isoeugenol catalyzed by Brassica juncea peroxidase and its cytotoxicity on MCF-7 cell line.
- Source :
-
AIP Conference Proceedings . 12/5/2022, Vol. 2493 Issue 1, p1-6. 6p. - Publication Year :
- 2022
-
Abstract
- By employing crude peroxidases extracted from sawi hijau (Brassica juncea) as biocatalyst, licarin A was synthesized from isoeugenol. The structure was elucidated and confirmed by mass spectrometer (MS) and nuclear magnetic resonance (NMR) analysis. This compound displayed moderate cytotoxicity effect on MCF-7 breast cancer cell with IC50 = 59.95±1.87 µg/mL, compared to doxorubicin with IC50 value of 0.88±0.34 µg/mL as the positive control. These results are indirectly in line with our previously published in silico tests which indicated that licarin A was not a potent ligand for estrogen receptor alpha (ERα), but either a non-ligand or a moderate ligand for ERα. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0094243X
- Volume :
- 2493
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- AIP Conference Proceedings
- Publication Type :
- Conference
- Accession number :
- 160625571
- Full Text :
- https://doi.org/10.1063/5.0109933