Effect of nanoparticles dewandaru fruits extract to reduce total cholesterol on hyperlipidemic mice.

Dewandaru (Eugenia uniflora L.) is a plant that contains flavonoids, tannins, terpenoids, and essential oils and used as traditional medicine. This study aimed to determine the activity of 70% ethanol extract of dewandaru fruit and nanoparticle form of dewandaru fruit extract (NP) to reduce total cholesterol levels in hyperlipidemic mice. DDY mice were divided into 8 treatment groups, each consisting of 4 mice: group I (Normal); group II (negative control); group III (positive control); group IV (dose 100 mg/kg bw); group V (dose 200 mg/kg bw); group VI (dose 400 mg/kg bw); group VII (NP dose 200 mg/kg bw) and group VIII (NP dose 400 mg/kg bw). Data of reducing cholesterol potential were analyzed using One way-Anova with the significant difference limit between the treatment group, and negative control is P<0,05. The experiment results showed dewandaru fruits extract and NP dewandaru potential as a herbal for hyperlipidemia treatment, and the highest decrease showed by NP dewandaru fruit extract dose 200 mg/kg bw. [ABSTRACT FROM AUTHOR]