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Cerebral Expression of the Neuregulin-1 Gene NRG1 during Induced Spatial Memory Impairment and Its Reversal in Aging Mice.
- Source :
-
Bulletin of Experimental Biology & Medicine . Nov2022, Vol. 174 Issue 1, p18-21. 4p. - Publication Year :
- 2022
-
Abstract
- We studied the effects of chronic intranasal administration of amyloidogenic fibrils of the proinflammatory protein S100A9 alone or in combination with glutamate antibodies on the expression of the neuregulin-1 gene (NRG1), a regulator of various physiological processes, in particular, regulation of neurogenesis and apoptosis, in the hippocampus, prefrontal cortex, and cerebellum of aging C57BL/6 mice under conditions of long-term memory disturbances. Under conditions of amnesia induced by S100A9 fibrils, pronounced (>90%) blockade of the expression of the NRG1 gene was found in all cerebral structures. Glutamate antibodies prevented/corrected disturbances in the cerebral expression of the NRG1 gene, thereby maintaining the activity of the NRG1/ErbB molecular signaling system, probably associated with the formation of spatial memory. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00074888
- Volume :
- 174
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bulletin of Experimental Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 160628210
- Full Text :
- https://doi.org/10.1007/s10517-022-05639-4