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Bio-fabricated zinc oxide and cry protein nanocomposites: Synthesis, characterization, potentiality against Zika, malaria and West Nile virus vector's larvae and their impact on non-target organisms.
- Source :
-
International Journal of Biological Macromolecules . Jan2023, Vol. 224, p699-712. 14p. - Publication Year :
- 2023
-
Abstract
- The role of mosquito vectors in spreading disastrous diseases to living organisms, especially to humans is inevitable and undeniable. The impacts of the available chemical and synthetic insecticides on non-specific organisms as well as on nature are being the reason behind the search for target-specific, biocompatible and eco-friendly alternatives. The Madhuca longifolia seed extract and cry proteins from Bacillus thuringiensis -based nanocomposites (Cp- Ml -ZnO NCs) were produced to conquer the above-mentioned issues. The Cp- Ml -ZnO NCs (100 μg/mL) expressed better scavenging potentiality on 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radicals than Ml seed extract and Ml -ZnO NPs. The susceptibility of tested vector larvae to the Cp- Ml -ZnO NCs was Ae. aegypti ˃An. stephensi ˃ Cx. quinquefasciatus along with LC 50 -27.73, 34.81, and 42.54 μg/mL concentration. The target specificity and biocompatibility of Cp- Ml -ZnO NCs were authenticated by the results obtained by evaluating the efficacy on D. similis , A. salina , P. reticulata , G. affinis , and RBCs of goat blood. Thus the Cp- Ml -ZnO NCs could be adopted for the control of vector larvae. • Nanocomposites (Cp- Ml -ZnO NCs) are successfully prepared using core shell technique. • Cp- Ml -ZnO NCs are having better antioxidant activity than Ml -ZnO NPs and extract. • Mosquito larval population was drastically controlled by the synthesized NCs. • Fortunately, they are biocompatible with non-specific Daphnia , Artemia and etc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 224
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 160847436
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2022.10.158