EFFECT OF HYPERICUM ALPESTRE AND RUMEXOB TUSIFOLIUS L. EXTRACTS ON THE ALTERATIONS OF PROLINE QUANTITY IN VARIOUS RAT ORGANS.

The effect of extracts of Hypericum alpestre and Rumex obtusifolius L herbals on the amount of free proline and the activity of proline biosynthesis enzymes in various organs of the rat was studied. It was shown that the activity of proline biosynthesis enzymes under the influence of R. obtusifolius L. extracts decreased in the liver by 74.7%, in the brain by 51.7%, and no changes in enzyme activity were observed in the kidneys. Compared with the control group, proline biosynthesis in the liver of rats under the action of extracts of H. alpestre was completely inhibited, in the brain – by 29%. Inhibition of the activity of proline biosynthesis enzymes is explained by the presence of severalbiologically active compounds with anti-inflammatory, antiproliferative, and anti-aging properties in the extracts of herbals. [ABSTRACT FROM AUTHOR]