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Bone marrow mesenchymal stem cells-derived exosomal microRNA-16-5p restrains epithelial-mesenchymal transition in breast cancer cells via EPHA1/NF-κB signaling axis.
- Source :
-
Genomics . May2022, Vol. 114 Issue 3, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- This study intends to conquer the mystery of microRNA-16-5p/erythropoietin-producing hepatocellular A1/nuclear factor-κB signaling (miR-16-5p/EPHA1/NF-κB signaling) in breast cancer. Expression of miR-16-5p, EPHA1 and NF-κB signaling-related proteins were detected. Gene overexpression or silencing was used to examine the biological roles of bone marrow mesenchymal stem cells (BMSCs)-derived exo -miR-16-5p in breast cancer. The effect of exo-miR-16-5p on tumorigenesis of breast cancer was confirmed by the xenograft nude mouse model. Low miR-16-5p and high EPHA1 expression were examined in breast cancer. BMSCs-derived exosomes, up-regulated miR-16-5p or down-regulated EPHA1 restrained epithelial-mesenchymal transition (EMT) of breast cancer cells and tumor growth in nude mice. Down-regulated miR-16-5p or up-regulated EPHA1 activated NF-κB signaling. Knockdown of EPHA1 or inhibition of NF-κB signaling reversed the effects of down-regulated miR-16-5p on breast cancer cells. BMSCs-derived exosomal miR-16-5p hinders breast cancer cells progression via EPHA1/NF-κB signaling axis. • Low miR-16-5p and high EPHA1 expression present in breast cancer. • BMSCs-derived exosomes deliver miR-16-5p to inhibit EMT in breast cancer. • MiR-16-5p targets EPHA1. • Down-regulated miR-16-5p or up-regulated EPHA1 activated NF-κB signaling. • Knockdown of EPHA1 or inhibition of NF-κB signaling reversed the effects of down-regulated miR-16-5p on breast cancer cell. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08887543
- Volume :
- 114
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 160863997
- Full Text :
- https://doi.org/10.1016/j.ygeno.2022.110341