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CLSPN is a potential biomarker associated with poor prognosis in low-grade gliomas based on a multi-database analysis.

Authors :
Jia, Yulong
Cheng, Xingbo
Liang, Wenjia
Lin, Shaochong
Li, Pengxu
Yan, Zhaoyue
Zhang, Meng
Ma, Wen
Hu, Chenchen
Wang, Baoya
Liu, Zhendong
Source :
Current Research in Translational Medicine. Sep2022, Vol. 70 Issue 4, pN.PAG-N.PAG. 1p.
Publication Year :
2022

Abstract

The oncogene CLSPN, also known as claspin, has regulatory effects in a variety of tumours; however, it is not clear whether CLSPN is a therapeutic target in low-grade gliomas (LGG). In this study, the prognostic value of CLSPN in LGG and its role as an immunotherapeutic target were evaluated. Transcriptome and methylation data for thousands of patients with glioma were collected from various databases, including The Cancer Genome Atlas, Chinese Glioma Genome Atlas, and Gene Expression Omnibus. Subsequently, a series of bioinformatics methods were used to evaluate the relationships between CLSPN and prognosis, clinical features, methylation status, immune cells, and molecular signaling pathways in LGG. CLSPN expression levels were positively correlated with major malignant characteristics of LGG, and low expression of CLSPN was associated with a better prognosis. The methylation sites cg04263115 and cg06100291 negatively regulated the expression of CLSPN , and increased methylation levels at these sites were related to a longer survival time in patients with LGG. CLSPN was positively correlated with tumour-infiltrating immune cells and showed high copy number variation in these cells. There was a positive regulatory relationship between CLSPN expression and programmed death-1 (PD-1) and programmed cell death ligand 1 (PD-L1). A gene set enrichment analysis revealed that CLSPN activates a variety of cancer signaling pathways. CLSPN was identified as an independent risk factor for LGG with excellent prognostic value. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
24523186
Volume :
70
Issue :
4
Database :
Academic Search Index
Journal :
Current Research in Translational Medicine
Publication Type :
Academic Journal
Accession number :
161017086
Full Text :
https://doi.org/10.1016/j.retram.2022.103345