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Enantioselective Hydrosilylation of β,β‐Disubstituted Enamides to Construct α‐Aminosilanes with Vicinal Stereocenters.
- Source :
-
Angewandte Chemie . 1/2/2023, Vol. 135 Issue 1, p1-7. 7p. - Publication Year :
- 2023
-
Abstract
- Despite the advances in the area of catalytic alkene hydrosilylation, the enantioselective hydrosilylation of alkenes bearing a heteroatom substituent is scarce. Here we report a rhodium‐catalyzed hydrosilylation of β,β‐disubstituted enamides to directly afford valuable α‐aminosilanes in a highly regio‐, diastereo‐, and enantioselective manner. Stereodivergent synthesis could be achieved by regulating substrate geometry and ligand configuration to generate all the possible stereoisomers in high enantio‐purity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROSILYLATION
*CONFIGURATIONS (Geometry)
*ALKENES
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 135
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 161064088
- Full Text :
- https://doi.org/10.1002/ange.202214534