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Transition from continuous to microglobular shaped peptide assemblies through a Liesegang-like enzyme-assisted mechanism.
- Source :
-
Journal of Colloid & Interface Science . Mar2023, Vol. 633, p876-885. 10p. - Publication Year :
- 2023
-
Abstract
- [Display omitted] Enzyme-assisted self-assembly confined within host materials leads to Liesegang-like spatial structuration when precursor peptides are diffusing through an enzyme-functionalized hydrogel. It is shown here that playing on peptide and enzyme concentrations results in a transition from continuous self-assembled peptide areas to individual microglobules. Their morphology, location, size and buildup mechanism are described. Additionally, it is also found that the enzymes adsorb onto the peptide self-assemblies leading to co-localization of peptide self-assembled microglobules and enzymes. Finally, we find that large microglobules grow at the expense of smaller ones present in their vicinity in a kind of Ostwald ripening process, illustrating the dynamic nature of the peptide self-assembly process within host hydrogels. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDES
*OSTWALD ripening
*PEPTIDE amphiphiles
*HYDROGELS
Subjects
Details
- Language :
- English
- ISSN :
- 00219797
- Volume :
- 633
- Database :
- Academic Search Index
- Journal :
- Journal of Colloid & Interface Science
- Publication Type :
- Academic Journal
- Accession number :
- 161080247
- Full Text :
- https://doi.org/10.1016/j.jcis.2022.11.034