Polyglutamic acid as raw material for drug carriers.

γ-PGA-PAE nanomaterials were prepared by spontaneous assembly of γ-PGA through condensation reaction, and preparation process of nanomaterials was optimized. HCPT/PGA-PAE nanospheres were prepared by using 10-hydroxycamptothecin as embedding drug, and the nanospheres prepared under the optimal conditions were characterized. The results showed that γ-PGA-PAE nanomaterials were successfully prepared with spherical shape and uniform distribution. HCPT/PGA-PAE nanospheres had high encapsulation rate and drug loading. The optimization of the processing conditions of nanomaterials by response surface method (RSM) is a feasible method to improve the utilization rate of γ-PGA, which provides a theoretical basis for the synthesis of nanomaterials in the future. [ABSTRACT FROM AUTHOR]