Female donor hearts can improve survival for male pediatric heart transplant recipients.

Background: Both gender‐ and weight‐matching between donor and recipient are thought to impact survival in pediatric heart transplantation, with clinical dogma holding that male donor hearts and "ideal" weight‐matching yield superior survival. The composite impacts of gender and weight on post‐transplant survival (PTS) are understudied. Methods: All pediatric (age <18) heart recipients between 1989 and 2021 with the complete recipient and donor gender and weight data were identified in the United Network for Organ Sharing database. Patients were grouped by recipient–donor gender (M & F) and donor‐to‐recipient weight ratio (DRWR; undersized [<0.8], ideal‐sized [0.8–1.5], oversized [>1.5]). Results: A total of 10 697 patients were identified. Among male recipients, PTS was greatest with oversized DRWR from either male or female donors (median 22.4 and 20.6 years; p <.001 vs. others) and lowest for undersized DRWR from either male or female donors (median 13.4 and 13.2 years; p <.001 vs. others). The majority (64%) of male recipients received ideal‐sized DRWR, among which female donor hearts yielded superior survival to males (median 18.9 vs. 17.4 years, p =.014). No differences in PTS existed for female recipients on the basis of gender‐match, DRWR, and gender/DRWR together (all p >.1). Conclusions: When considered together, gender and DRWR pairings impact PTS in male—but not female—pediatric heart transplant recipients. For males receiving ideal‐sized DRWR organs (most common pairing, >60%), male recipients achieve superior survival when female donor hearts are transplanted. These findings suggest that if weight is being used for size‐matching, donor gender should also be considered, particularly for male recipients. [ABSTRACT FROM AUTHOR]