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(SCp)Rhodium‐Catalyzed Asymmetric Satoh–Miura Reaction for Building‐up Axial Chirality: Counteranion‐Directed Switching of Reaction Pathways.
- Source :
-
Angewandte Chemie . 1/16/2023, Vol. 135 Issue 3, p1-6. 6p. - Publication Year :
- 2023
-
Abstract
- Satoh–Miura reaction is an important method for extending π‐systems by forging multi‐substituted benzene rings via double aryl C−H activation and annulation with alkynes. However, the development of highly enantioselective Satoh–Miura reaction remains rather challenging. Herein, we report an asymmetric Satoh–Miura reaction between 1‐aryl benzo[h]isoquinolines and internal alkynes enabled by a SCpRh‐catalyst. Judiciously choosing the counteranion of the Rh‐catalyst is crucial for the desired reactivity over the competitive formation of azoniahelicenes. Detailed mechanistic studies support the proposal of counteranion‐directed switching of reaction pathways in Rh‐catalyzed asymmetric C−H activation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHIRALITY element
*ANNULATION
*ISOQUINOLINE synthesis
*ALKYNES
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 135
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 161214311
- Full Text :
- https://doi.org/10.1002/ange.202214460