Noninvasive ultrasound assessment of tissue internal pressure using dual mode elasticity imaging: a phantom study.

Objective. Tissue internal pressure, such as interstitial fluid pressure in solid tumors and intramuscular pressure in compartment syndrome, is closely related to the pathological state of tissues. It is of great diagnostic value to measure and/or monitor the internal pressure of targeted tissues. Because most of the current methods for measuring tissue pressure are invasive, noninvasive methods are highly desired. In this study, we developed a noninvasive method for qualitative assessment of tissue internal pressure based on a combination of two ultrasound elasticity imaging methods: strain imaging and shear wave elasticity imaging. Approach. The method was verified through experimental investigation using two tissue-mimicking phantoms each having an inclusion confined by a membrane, in which hydrostatic pressures can be applied and maintained. To examine the sensitivity of the elasticity imaging methods to pressure variation, strain ratio and shear modulus ratio (SMR) between the inclusion and background of phantom were obtained. Main results. The results first experimentally prove that pressure, in addition to elasticity, is a contrast mechanism of strain imaging, and further demonstrate that a comparative analysis of strain ratio and SMR is an effective method for noninvasive tissue internal pressure detection. Significance. This work provides a new perspective in interpreting the strain ratio data in medical diagnosis, and it also provides a noninvasive alternative for assessing tissue internal pressure, which could be valuable for the diagnosis of pressure-related diseases. [ABSTRACT FROM AUTHOR]