Mitigation of malathion induced toxicity in developing chicken embryo using Zingiber officinale and Curcuma longa extracts.

A number of biological and pharmacological benefits have been attributed to ginger and turmeric, but limited studies have been done to show the positive effects of ginger and turmeric extracts on embryo development in model animals such as chickens and their neutralizing effect to reduce the toxicity of pesticides. The aqueous extracts of ginger and turmeric were screened for their effect on embryo development after treatment of fertilized eggs with malathion. Ginger and turmeric extracts significantly increased the crown-rump (CR) and body weight measurement when compared with control groups after administration of malathion. A dose-dependent response was observed indicating that increase in the aqueous plant extracts concentrations resulted in increase in percent mortality of chick embryos. Administration of ginger resulted in 95.5 % increase in wet body weight and 19.5 % increase in CR measurement of 7-days embryo. While administration of turmeric resulted in 59.7 % increase in wet body weight and 19.9 % increase in diameter of CR of 7-days old embryo as compared to controls. Similarly, administration of ginger extract also reduced percent mortality (30-50 % decrease) in embryos treated with malathion, whereas turmeric reduced percent mortality up to 40 %, when a dose of 100 µgmL-1 of malathion was injected. In short, ginger and turmeric extracts significantly increased the growth parameters of embryo development in chicken by mitigating the toxicity of malathion. A number of biological and pharmacological benefits have been attributed to ginger and turmeric, but limited studies have been done to show the positive effects of ginger and turmeric extracts on embryo development in model animals such as chickens and their neutralizing effect to reduce the toxicity of pesticides. The aqueous extracts of ginger and turmeric were screened for their effect on embryo development after treatment of fertilized eggs with malathion. Ginger and turmeric extracts significantly increased the crown-rump (CR) and body weight measurement when compared with control groups after administration of malathion. A dose-dependent response was observed indicating that increase in the aqueous plant extracts concentrations resulted in increase in percent mortality of chick embryos. Administration of ginger resulted in 95.5 % increase in wet body weight and 19.5 % increase in CR measurement of 7-days embryo. While administration of turmeric resulted in 59.7 % increase in wet body weight and 19.9 % increase in diameter of CR of 7-days old embryo as compared to controls. Similarly, administration of ginger extract also reduced percent mortality (30-50 % decrease) in embryos treated with malathion, whereas turmeric reduced percent mortality up to 40 %, when a dose of 100 µgmL-1 of malathion was injected. In short, ginger and turmeric extracts significantly increased the growth parameters of embryo development in chicken by mitigating the toxicity of malathion. [ABSTRACT FROM AUTHOR]