The effect of brain functional network following electroconvulsive therapy in major depressive disorder.

Purpose: The purpose of this paper is to examine the changes of brain functional network after electroconvulsive therapy (ECT) treatment in major depressive disorder (MDD). Design/methodology/approach: In this study, resting electroencephalography (EEG) is used to explore the changes in spectral power density, functional connectivity and network topology elicited by an acute open-label course of ECT in a group of 19 MDD subjects. The brain functional network based on Pearson correlation is constructed in a continuous threshold space (0.38–0.59). Complex network theory is used to analyze the network characteristic such as the length of the characteristic path, clustering coefficient, degree, betweenness centrality, global efficiency and small-world architecture. Findings: The results show that ECT increased the spectral power density of Delta, Theta and Alpha1 bands and the full frequency. ECT increases the functional connectivity in Delta and full frequency and reduces the functional connectivity in Alpha2 band. In the selected threshold space, the clustering coefficient, global efficiency and small-world attributes of the network are changed significantly after ECT. Originality/value: The findings indicate that resting EEG could effectively characterize the changes of brain functional networks following ECT in MDD. The results provide a theoretical basis to explore the neurophysiological mechanism of ECT in the field of MDD treatment. [ABSTRACT FROM AUTHOR]