乳腺癌对比增强能谱乳腺 X 线摄影与免疫组化标记物的相关性研究.

Objective To study the difference between the positive and negative immunohistochemical markers in the morphological features of contrast-enhanced spectral mammography (CESM), and analyze its clinical significance. Methods 88 patients with pathologically confirmed breast cancer underwent CESM and immunohistochemical marker detection including estrogen receptor (ER), progesterone receptor (PR), human epidermis growth factor receptor-2 (HER-2) and cell proliferation antigen markers (Ki-67). The morphological features of lesions on CESM including the size, margin, morphology, microcalcification, and degree of contrast enhancement were retrospectively analyzed. Correlation analysis with immunohistochemical markers was performed. Results The 88 lesions were invasive carcinoma (64), intraductal carcinoma-in-situ (10), invasive carcinoma with intraductal carcinoma-in-situ (10), invasive carcinoma with papillary carcinoma (2), and intraductal carcinoma with papillary carcinoma (2) . The positive rates of immunohistochemical markers were 61.36% ER+, 50.00% PR+, 70.45% HER-2+, and 84.09% Ki-67+. There was significant correlation between tumor size and Ki-67positive expression (P=0.003) ; morphology and PR (P=0.031) and HER-2 (P=0.001) positive expressions; microcalcification and Ki-67positive expression (P=0.009) ; “burr sign” and ER positive expression (P=0.020) ; the degree of enhancement and HER-2 (P=0.014) and Ki-67 (P=0.030) positive expression. Conclusion Morphological characteristics of CESM correlate with immunohistochemical markers and are valuable in the diagnosis, treatment and prognosis assessment of breast cancer. [ABSTRACT FROM AUTHOR]