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Social Enhancement of Adult Neurogenesis in Zebrafish is Not Regulated by Cortisol.
- Source :
-
Neuroscience . Jan2023, Vol. 509, p51-62. 12p. - Publication Year :
- 2023
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Abstract
- • We tested how the social environment and cortisol exposure (acute/chronic) affect adult neurogenesis in zebrafish. • Cell proliferation is dependent on the valence of the social environment (positive > negative). • Cell proliferation is independent of either acute or chronic cortisol exposure. • Thus, there is a key role of the social environment in adult neurogenesis in zebrafish independently of cortisol modulation. In Mammals adult neurogenesis is influenced by environmental conditions, and the glucocorticoid hormones (GC) play a major role in this regulation. In contrast in fish, the study of the effects of cortisol on the regulation of environmental driven adult neurogenesis has produced conflicting results. While in some species elevated cortisol levels impair cell proliferation, in others, it promotes cell proliferation and differentiation. This lack of consistency may be explained by methodological differences across studies, namely in the stimuli and/or cortisol treatments used. Here, we tested the effects of the social environment on adult neurogenesis, considering a positive and a negative social context, and different durations of cortisol exposure. We hypothesise that there is an interaction between the valence of the social environment and cortisol, such that elevated acute cortisol experienced during social interactions only have a detrimental effect on neurogenesis in negative social contexts. Therefore, fish were exposed to a positive (conspecific shoal) or negative (predator) social experience, and the interaction between the valence of the social context and cortisol exposure (acute and chronic) was tested. Our results indicate that adult neurogenesis is modulated by the social environment, with the number of newly generated cells being dependent on the valence of the social information (positive > negative). These effects were independent of cortisol, either for acute or chronic exposure, highlighting the social environment as a key factor in the modulation of cell proliferation in the adult zebrafish brain, and rejecting a role for cortisol in this modulation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUROGENESIS
*BRACHYDANIO
*HYDROCORTISONE
*SOCIAL context
*CELL proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 03064522
- Volume :
- 509
- Database :
- Academic Search Index
- Journal :
- Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 161343686
- Full Text :
- https://doi.org/10.1016/j.neuroscience.2022.11.007