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Synthesis of Picramide Using Nitration and Ammonolysis in Continuous Flow.
- Source :
-
Chemistry - An Asian Journal . 1/17/2023, Vol. 18 Issue 2, p1-5. 5p. - Publication Year :
- 2023
-
Abstract
- This paper describes a safer, scalable and continuous process for synthesis of picramide. The process consists of two steps: step‐1. nitration of p‐nitroanisole (PNAN) to 2,4,6‐trinitrianisole (TNAN); step‐2. ammonolysis of TNAN to picramide. Both the steps were optimized in flow, with yield of 90% and 98% in step‐1 and step‐2 respectively. Picramide with HPLC purity greater than 99% was obtained. When compared with batch, in step‐1, flow process provided significant advantage in selectivity and yield. The optimized flow process was scaled to 25 g/hr production rate in a laboratory flow reactor. The method can be considered fit for the safe production of picramide at commercial scale. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 161366223
- Full Text :
- https://doi.org/10.1002/asia.202201028