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Multifunctional tadpole-like bimetallic nanoparticles realizes synergistic sterilization with chemical kinetics and photothermal therapy.
- Source :
-
Applied Catalysis B: Environmental . May2023, Vol. 325, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Bacterial infection has become a global health issue. The misuse of antibiotics has been resulting in increased drug resistance and bioaccumulation. Therefore, developing a highly safe antibacterial agent, with high antibacterial performance is demanding. Inspired by the natural motors performing automated tasks in complicated living environments, we demonstrate tadpole-like nanoparticles (TNPs) with several functions, including high photothermal conversion efficiency, peroxidase-like catalytic activity, glutathione peroxidase-like activity, and catalase-like activity. TNPs produce hydroxyl radical (•OH) at an extremely low concentration of hydrogen peroxide of 0.006%, which can damage bacterial cell membranes, proteins, and DNA. Moreover, the glutathione peroxidase-like activity disrupts the anti-oxidative mechanism of bacteria and improves the permeability of the cell membranes, consequently enhancing the killing effect of ROS. In addition, TNPs possess tadpole-like asymmetry to overcome Brownian motion, demonstrating strong directional motion propelled by O 2. The in vivo experiments indicate that TNPs could also shorten the inflammatory period and promote angiogenesis, making them a very promising antibacterial agent. [Display omitted] • A tadpole-like NPs with PTT, peroxidase-like catalytic, glutathione peroxidase-like, and catalase-like activity are synthesis. • The glutathione peroxidase-like activity improves the permeability of the cell membranes. • TNPs could also shorten the inflammatory period and promote angiogenesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09263373
- Volume :
- 325
- Database :
- Academic Search Index
- Journal :
- Applied Catalysis B: Environmental
- Publication Type :
- Academic Journal
- Accession number :
- 161440225
- Full Text :
- https://doi.org/10.1016/j.apcatb.2022.122314