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Characterization of the human peripheral effector cells mediating antibody dependent cellular cytotoxicity against allogenic cells.
- Source :
-
Clinical & Experimental Immunology . Dec1979, Vol. 38 Issue 3, p549-560. 12p. - Publication Year :
- 1979
-
Abstract
- The effector cell populations in human peripheral blood responsible for antibody-dependent cellular cytotoxicity against allogenic cells coated with HLA polyspecific antibodies were investigated using several separation techniques including preparative electrophoresis. Electrophoresis produced a marked effector cells enrichment in a range of 2-5 fractions which exhibited an intermediary electrophoretic mobility. Monocytic cells do not contribute an effector mechanism but minor subsets of polymorphonuclear cells and nylon wool non-adherent non-phagocytic lymphocytes displayed ADCC. Both effector cell populations were found to exhibit a similar electrical charge of cell surface centered around -1.05 μm · sec-1 V-1 cm. These observations provided a precise biophysical basis for the identification of effector cells in ADCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 38
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16145566