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Irreversible Site‐Specific Hydrazinolysis of Proteins by Use of Sortase.
- Source :
-
Angewandte Chemie . Feb2014, Vol. 126 Issue 8, p2230-2234. 5p. - Publication Year :
- 2014
-
Abstract
- Sortase‐mediated hydrazinolysis of proteins with hydrazine or its derivatives was developed for the production of recombinant protein hydrazides. This process provides an alternative approach for protein semisynthesis through the use of recombinant protein hydrazides as thioester surrogates. It also provides an alternative method for C‐terminal modification of proteins with functional units as well as for the preparation of C‐to‐C fusion proteins. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RECOMBINANT proteins
*PROTEINS
*HYDRAZINE derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 126
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 161473396
- Full Text :
- https://doi.org/10.1002/ange.201310010