The role of BMI1 in endometrial cancer and other cancers.

• Summary of the structure and upstream regulatory mechanisms of BMI1. • Underlying role of BMI1 in EC and in chemoradiotherapy resistance of other cancers. • Summary of current drugs targeting BMI1 and the treatment application limitations. Endometrial cancer (EC) is the third leading gynecological malignancy, and its treatment remains challenging. B cell-specific Moloney murine leukemia virus integration site-1 (BMI1) is one of the core members of the polycomb group (PcG) family, which plays a promoting role in the occurrence and development of various tumors. Notably, BMI1 has been found to be frequently upregulated in endometrial cancer (EC) and promote the occurrence of EC through promoting epithelial-mesenchymal transition (EMT) and AKT/PI3K pathways. This review summarizes the structure and upstream regulatory mechanisms of BMI1 and its role in EC. In addition, we focused on the role of BMI1 in chemoradiotherapy resistance and summarized the current drugs that target BMI1. [ABSTRACT FROM AUTHOR]