Development of poly(lactide-co-glycolide) microparticles for sustained delivery of meloxicam.

Poly(lactide- co -glycolide) (PLGA) polymers have been widely used for drug delivery due to their biodegradability and biocompatibility. One of the objectives of encapsulating a drug in PLGA microparticles (MPs) is to achieve an extended supply of the drug through sustained release, which can range from weeks to months. Focusing on the applications needing a relatively short-term delivery, we investigated formulation strategies to achieve a drug release from PLGA MPs for two weeks, using meloxicam as a model compound. PLGA MPs produced by the traditional oil/water (O/W) single emulsion method showed only an initial burst release with minimal increase in later-phase drug release. Alternatively, encapsulating meloxicam as solid helped reduce the initial burst release. The inclusion of magnesium hydroxide [Mg(OH) 2 ] enhanced later-phase drug release by neutralizing the developing acidity that limited the drug dissolution. The variation of solid meloxicam and Mg(OH) 2 quantities allowed for flexible control of meloxicam release, yielding MPs with distinct in vitro release kinetics. When subcutaneously injected into rats, the MPs with relatively slow in vitro drug release kinetics showed in vivo drug absorption profiles consistent with in vitro trend. However, the MPs that rapidly released meloxicam showed an attenuated in vivo absorption, suggesting premature precipitation of fast-released meloxicam. In summary, this study demonstrated the feasibility of controlling drug release from the PLGA MPs over weeks based on the physical state of the encapsulated drug and the inclusion of Mg(OH) 2 to neutralize the microenvironmental pH of the MPs. [Display omitted] • Meloxicam was encapsulated in PLGA microparticles for sustained release over 2 weeks. • Encapsulation of meloxicam in the solid state reduced the initial burst release. • Inclusion of Mg(OH) 2 enhanced drug release in the later phase. • Microparticles showed a consistent trend in in vivo drug absorption as in vitro results when the release was relatively slow. [ABSTRACT FROM AUTHOR]