Recycling of parental histones preserves the epigenetic landscape during embryonic development.

The article highlights a study on Drosophila HisC mutant embryos harboring a deletion of all canonical histone genes, in which nucleosome assembly relies on parental histones from cell cycle 14 onward. It discusses that the genomic positions of modified parental histone H2A, H2B, and H3 are largely restored during DNA replication; and concludes that parental histones are recycled to preserve the epigenetic landscape during DNA replication in vivo.