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Pancreatic Beta-cell Dysfunction in Type 2 Diabetes.
- Source :
-
European Journal of Inflammation . 1/30/2023, p1-13. 13p. - Publication Year :
- 2023
-
Abstract
- Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a narrow range. Defects in the function and mass of β-cells play a significant role in the development and progression of diabetes. Increased β-cell deficiency and β-cell apoptosis are observed in the pancreatic islets of patients with type 2 diabetes. At an early stage, β-cells adapt to insulin resistance, and their insulin secretion increases, but they eventually become exhausted, and the β-cell mass decreases. Various causal factors, such as high glucose, free fatty acids, inflammatory cytokines, and islet amyloid polypeptides, contribute to the impairment of β-cell function. Therefore, the maintenance of β-cell function is a logical approach for the treatment and prevention of diabetes. In this review, we provide an overview of the role of these risk factors in pancreatic β-cell loss and the associated mechanisms. A better understanding of the molecular mechanisms underlying pancreatic β-cell loss will provide an opportunity to identify novel therapeutic targets for type 2 diabetes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1721727X
- Database :
- Academic Search Index
- Journal :
- European Journal of Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 161663403
- Full Text :
- https://doi.org/10.1177/1721727X231154152