Photoinduced α‐Alkylation of Tetrahydroisoquinolines with Organoboron Reagent Enabled by Organic Photocatalyst.

We describe an efficient method for α‐functionalization of N‐aryl‐tetrahydroisoquinolines under visible‐light‐irradiation catalyzed by organic photocatalyst. This protocol provides a concise and environmental approach for the rapid allylation and benzylation of N‐aryl‐tetrahydroisoquinolines, and shows broad substrate scope. Stable organoboron reagents have shown their ability in the construction of challenging Csp3−Csp3 bond. The load of the photocatalyst is low and the oxidant is inexpensive and less toxic. [ABSTRACT FROM AUTHOR]